For active development of new boards, migrate to OrCAD 22.x or KiCad. For maintenance of old boards, the virtual machine with 16.3 build 33 is perfectly safe and stable.
If possible, move to or 17.4 for:
For optimal performance with OrCAD 16.3, the following hardware specifications are recommended: cadence orcad 163 33
Some less common references:
Cadence uses a FlexLM-based license manager. Ensuring the environment variables (like CDS_LIC_FILE ) are correctly set is the most common hurdle during setup. For active development of new boards, migrate to OrCAD 22