The film was widely parodied in mainstream media, most notably in the South Park episode "HUMANCENTiPAD" and various internet memes. This dark humor brought the film to the attention of audiences who do not usually watch horror.
Bagi penonton lokal, kendala bahasa sering kali menjadi hambatan utama dalam menikmati film asing. Pencarian subtitle bahasa Indonesia (Sub Indo) untuk film ini mencerminkan dinamika tertentu dalam komunitas pencinta film: 1. Rasa Penasaran yang Tinggi (Morbid Curiosity) The Human Centipede Sub Indo