Generally, no. Cookie Clicker does not have a cheat detection system, and editing your save file does not typically prevent you from earning Steam achievements. However, introducing illegal or invalid data might cause strange behavior. It's always best to make small, logical changes.
Version 2.022 added specific nuances to the game economy. When using an editor, focus on these high-impact variables to maximize your gameplay efficiency: cookie clicker save editor v2 022 best